Newcastle University

Institute for Cell and Molecular Biosciences (ICaMB): ICaMB is one of the research institutes within Newcastle University. It is cited in the Medical School Building in the Catherine Cookson Building and the Centre for Macterial Cell Biology. ICaMB consists of ~50 academics and 90 Ph.D. students and 60 RA1As with expertise in molecular and cellular biology, structural biology and enzymology. Within ICaMB there is considerable expertise in expressing and purifying recombinant proteins. and studying protein ligand interactions. The Institute has state of the art equipment for carbohydrate structure analysis and carbohydrate-protein interactions including isothermal titration calorimetry, mass spectrometry, NMR, isothermal titration calorimetry, surface plasmon resonance, fluorescence and UV difference spectroscopy. ICaMB also has a structural biology laboratory that houses a protein crystallization robot, X-ray generator and detector and has ample synchrotron time.


Professor Harry J. Gilbert (HJG): gained his PhD from the University of Southampton in 1979, worked for five years at the PHLS Centre for Applied Microbiology and Research. HJG moved to a lectureship at Newcastle University in 1985, becoming professor in 1992. He worked for two years from 2008-2010 at the Complex Carbohydrate Research Centre at UGA, USA. HJG is interested in the structure and function of carbohydrate modifying enzymes. His group analyse both the mechanism of catalysis and substrate recognition, and are engaged in the discovery of novel enzymes of industrial utility. The major focus of the research team is to understand how glycoside hydrolases can access and cleave their target substrates within the plant cell wall, which, through its chemical and physical complexity, is recalcitrant to biological attack. HJG is funded by the BBSRC, Wellcome Trust and the European Research Council.